The two have been in talks for several months and are expected to sign a deal imminently.
Channel 4’s content is expected to be branded in the same way as Channel 4 On Demand, the broadcaster’s online catch up service.
The partnership will add to Channel 4 online access to programmes, allowing viewers to watch content via YouTube for 30 days after it airs on television.
As part of the deal, Channel 4 is thought to have negotiated the right sell the adverts around its content and share the revenues with YouTube.
The Google-owned site has similar tie-ups with US broadcasters but it would mark the first of its kind in the UK.
In February this year, the Competition Commission vetoed Project Kangaroo, a deal between the BBC, ITV and Channel 4 to make programmes accessible via a shared on-demand platform.
Channel 4 and Google declined to comment.