The iPhone will retail in all 402 Orange shops, online, Orange HMV concessions, Carphone Warehouse, Phones4U and elsewhere.
The company has developed offers such as a free iPhone for a 24 month contract at £30 a month. The 3G and 3GS handsets will be available to Orange pay-as-you-go, pay monthly and business customers.
A number of Orange stores will celebrate the arrival of the iPhone with early opening at 7 am on 10 November.
The company has seen more than a quarter of a million customers register their interest on our website.
Vodafone is also poised to start selling Apple iPhones.